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- Title
Hypoxia-Inducible Factor-1α: A Potential Factor for the Enhancement of Osseointegration between Dental Implants and Tissue-Engineered Bone.
- Authors
Duohong Zou; Siheng Zhu; Jian Zhou; Jiacai He; Yuanyin Wang; Zhihong Xie; Wei Han; Sulan You; Yuanliang Huang
- Abstract
Introduction: Tissue-engineered bones are widely utilized to protect healthy tissue, reduce pain, and increase the success rate of dental implants. one of the most challenging obstacles lies in obtaining effective osseointegration between dental implants and tissueengineered structures. Deficiencies in vascularization, osteogenic factors, oxygen, and other nutrients inside the tissue-engineered bone during the early stages following implantation all inhibit effective osseointegration. Oxygen is required for aerobic metabolism in bone and blood vessel tissues, but oxygen levels inside tissueengineered bone are not sufficient for cell proliferation. HIF-1α is a pivotal regulator of hypoxic and ischemic vascular responses, driving transcriptional activation of hundreds of genes involved in vascular reactivity, angiogenesis, arteriogenesis, and osteogenesis. The hypothesis: Hypoxia-Inducible Factor-1α seems a potential factor for the enhancement of osseointegration between dental implants and tissue-engineered bone. Evaluation of the hypothesis: Enhancement of HIF-1α protein expression is recognized as the most promising approach for angiogenesis, because it can induce multiple angiogenic targets in a coordinated manner. Therefore, it will be a novel potential therapeutic methods targeting HIF-1α expression to enhance osseointegration between dental implants and tissue-engineered bone.
- Subjects
DENTAL implants; TISSUE engineering; HYPOXEMIA
- Publication
Dental Hypotheses, 2011, Vol 2, Issue 3, p118
- ISSN
2155-8213
- Publication type
Article
- DOI
10.5436/j.dehy.2011.2.00037