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- Title
Fused in sarcoma (FUS) inhibits milk production efficiency in mammals.
- Authors
Shao, Haili; Huang, Jipeng; Wang, Hui; Wang, Guolei; Yang, Xu; Cheng, Mei; Sun, Changjie; Zou, Li; Yang, Qin; Zhang, Dandan; Liu, Zhen; Jiang, Xuelong; Shi, Lei; Shi, Peng; Han, Baowei; Jiao, Baowei
- Abstract
Efficient milk production in mammals confers evolutionary advantages by facilitating the transmission of energy from mother to offspring. However, the regulatory mechanism responsible for the gradual establishment of milk production efficiency in mammals, from marsupials to eutherians, remains elusive. Here, we find that mammary gland of the marsupial sugar glider contained milk components during adolescence, and that mammary gland development is less dynamically cyclic compared to that in placental mammals. Furthermore, fused in sarcoma (FUS) is found to be partially responsible for this establishment of low efficiency. In mouse model, FUS inhibit mammary epithelial cell differentiation through the cyclin-dependent kinase inhibitor p57Kip2, leading to lactation failure and pup starvation. Clinically, FUS levels are negatively correlated with milk production in lactating women. Overall, our results shed light on FUS as a negative regulator of milk production, providing a potential mechanism for the establishment of milk production from marsupial to eutherian mammals. Efficient milk production in mammals confers advantages by facilitating the transmission of energy from mother to offspring. However, the factors for establishing the efficiency in mammals are unknown. Here, the authors identify FUS as a regulator of efficient milk production in mammals.
- Subjects
MILK yield; CYCLIN-dependent kinase inhibitors; SARCOMA; MAMMARY glands; CYCLIN-dependent kinases; CELL differentiation; MILK proteins
- Publication
Nature Communications, 2024, Vol 15, Issue 1, p1
- ISSN
2041-1723
- Publication type
Article
- DOI
10.1038/s41467-024-48428-5