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- Title
INTRAOPERATIVE AND POSTOPERATIVE EFFECTS OF DEXMEDETOMIDINE ON HAEMODYNAMIC STRESS RESPONSES TO SURGERIES.
- Authors
Naik, M. Anand Babu; Pavani; Devireddy, Swetha; Sai Charan, Mydavolu Venkata
- Abstract
Introduction: Stress response to surgery is characterized by increase in secretion of endocrinal system and activation of immunological and sympathetic nervous system. Alpha 2-adrenoceptor agonists have several beneficial actions during the perioperative period. They decrease sympathetic tone, with attenuation of the neuroendocrine and hemodynamic responses to anaesthesia and surgery; reduce anaesthetic and opioid requirements; and cause sedation and analgesia. Aims and objectives; The objective of this study is to evaluate the intra-operative, and postoperative haemodynamic stress responses in patients, when Dexmedetomidine is used as an anaesthetic adjunct. Materials and Method: After the approval from Ethical Committee of Guntur medical college, Guntur, A.P, 100 patients scheduled for elective surgery planned to be done under general anaesthesia were included in the study.Patients were randomly divided into two equal groups, according to the study drug administered, each group include 50 patients in number (n=50), group I (the control or placebo group) and group II (Dexmedetomidine group). Patients received either Dexmedetomidine hydrochloride (available as 100 μg/ml ) in group II or saline solution in group I in equal amount. Data were collected and entered into the software STATA (version 11.0). P<0.05 was considered significant and P>0.05 was considered insignificant. Results: There was no significant difference in the base line parameters among the groups. Dexmedetomidine decreased heart rate significantly compared to control group. Dexmedetomidine reduced the intraoperative use of Propofol and Fentanyl significantly compared to control group. Conclusion: The perioperative infusion of Dexmedetomidine appears to be effective to attenuate stress induced haemodynamic fluctuation, reduced Propofol requirements, decreased the intra and post-operative narcotic analgesic administration, produced perioperative sedation in patients who underwent elective surgeries when compared with placebo.
- Subjects
DEXMEDETOMIDINE; SYMPATHETIC nervous system; HEMODYNAMICS; ELECTIVE surgery; ANALGESIA; HEART beat; SALINE solutions
- Publication
Journal of Cardiovascular Disease Research (Journal of Cardiovascular Disease Research), 2024, Vol 15, Issue 6, p627
- ISSN
0975-3583
- Publication type
Article