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- Title
Lactobacillus helveticus -Derived Whey-Calcium Chelate Promotes Calcium Absorption and Bone Health of Rats Fed a Low-Calcium Diet.
- Authors
Hu, Wei; Pei, Zhiwen; Xia, Aonan; Jiang, Yang; Yang, Bo; Liu, Xiaoming; Zhao, Jianxin; Zhang, Hao; Chen, Wei
- Abstract
This study investigated the characteristics of Lactobacillus helveticus-derived whey-calcium chelate (LHWCC) and its effect on the calcium absorption and bone health of rats. Fourier-transform infrared spectroscopy showed that carboxyl oxygen atoms, amino nitrogen atoms, and phosphate ions were the major binding sites with calcium in LHWCC, which has a sustained release effect in simulated in vitro digestion. LHWCC had beneficial effects on serum biochemical parameters, bone biomechanics, and the morphological indexes of the bones of calcium-deficient rats when fed at a dose of 40 mg Ca/kg BW for 7 weeks. In contrast to the inorganic calcium supplement, LHWCC significantly upregulated the gene expression of transient receptor potential cation V5 (TRPV5), TRPV6, PepT1, calcium-binding protein-D9k (Calbindin-D9k), and a calcium pump (plasma membrane Ca-ATPase, PMCA1b), leading to promotion of the calcium absorption rate, whereas Ca3(PO4)2 only upregulated the TRPV6 channel in vivo. These findings illustrate the potential of LHWCC as an organic calcium supplement.
- Subjects
BACTERIAL proteins; BONES; CARRIER proteins; RESEARCH funding; CALCIUM-binding proteins; DIETARY calcium; IN vivo studies; CALCIUM; GENE expression; RATS; INFRARED spectroscopy; LACTOBACILLUS; ANIMAL experimentation; WHEY proteins; DIETARY supplements
- Publication
Nutrients, 2024, Vol 16, Issue 8, p1127
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu16081127