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- Title
B Cells Dynamic in Aging and the Implications of Nutritional Regulation.
- Authors
Yu, Yifei; Lu, Chenxu; Yu, Weiru; Lei, Yumei; Sun, Siyuan; Liu, Ping; Bai, Feirong; Chen, Yu; Chen, Juan
- Abstract
Aging negatively affects B cell production, resulting in a decrease in B-1 and B-2 cells and impaired antibody responses. Age-related B cell subsets contribute to inflammation. Investigating age-related alterations in the B-cell pool and developing targeted therapies are crucial for combating autoimmune diseases in the elderly. Additionally, optimal nutrition, including carbohydrates, amino acids, vitamins, and especially lipids, play a vital role in supporting immune function and mitigating the age-related decline in B cell activity. Research on the influence of lipids on B cells shows promise for improving autoimmune diseases. Understanding the aging B-cell pool and considering nutritional interventions can inform strategies for promoting healthy aging and reducing the age-related disease burden.
- Subjects
B cells; ACTIVE aging; NUTRITIONAL requirements; AUTOIMMUNE diseases; AGING; PATHOGENIC microorganisms; IMMUNITY; SYSTEMIC lupus erythematosus; BLOODBORNE infections; OLD age
- Publication
Nutrients, 2024, Vol 16, Issue 4, p487
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu16040487