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- Title
Association between Gestational Weight Gain and Risk of Hypertensive Disorders of Pregnancy among Women with Obesity: A Multicenter Retrospective Cohort Study in Japan.
- Authors
Ito, Momoka; Kyozuka, Hyo; Yamaguchi, Tomoko; Sugeno, Misa; Murata, Tsuyoshi; Hiraiwa, Tsuyoshi; Ito, Fumihiro; Suzuki, Daisuke; Fukuda, Toma; Yasuda, Shun; Fujimori, Keiya; Nomura, Yasuhisa
- Abstract
The relationship between weight gain during pregnancy and the onset of hypertensive disorders of pregnancy in women with pre-pregnancy obesity remains unclear. We examined the effects of weight gain during pregnancy on hypertensive disorders of pregnancy among women with pre-pregnancy body mass index (BMI) ≥ 25.0 kg/m2. This multicenter retrospective cohort study included nullipara women who delivered at two units in Japan between 1 January 2013, and 31 December 2020. Singleton primipara (n = 3040) were categorized into two pre-pregnancy BMI groups: 25.0–<30.0, and ≥30.0 kg/m2. Using multiple logistic regression analyses (reported as adjusted odds ratio and 95% confidence interval), gestational weight gain effects on overall hypertensive disorders of pregnancy, gestational hypertension, and pre-eclampsia were determined. Gestational weight gain increased hypertensive disorders of pregnancy (1.09, 1.03–1.16, p < 0.05) and pre-eclampsia risk (1.10, 1.01–1.20, p < 0.05) among the BMI 25.0–<30.0 kg/m2 group and hypertensive disorders of pregnancy risk among the ≥30.0 kg/m2 group (1.07, 1.00–1.05, p < 0.05). Using receiver operating characteristic curve analyses, among the BMI 25.0–<30.0 kg/m2 group, for hypertensive disorders of pregnancy (area under the curve [AUC], 0.63, p < 0.05) and pre-eclampsia (AUC, 0.62; p < 0.05), the weight gain cut-off was 10.5 and 10.6 kg, with sensitivity/specificity of 0.47/0.73 and 0.50/0.73, respectively. For the BMI ≥30.0 kg/m2 group (AUC, 0.63, p < 0.05), the cut-off was 3.5 kg (sensitivity/specificity, 0.75/0.49). The optimal gestational weight gain for reducing hypertensive disorders of pregnancy among women with a pre-pregnancy BMI > 25 kg/m2 may facilitate personalized pre-conception counseling among women with obesity.
- Subjects
JAPAN; HYPERTENSION risk factors; RISK factors of preeclampsia; WEIGHT gain in pregnancy; HYPERTENSION in pregnancy; RESEARCH; OBESITY; CONFIDENCE intervals; MULTIPLE regression analysis; PREGNANT women; RETROSPECTIVE studies; RISK assessment; DESCRIPTIVE statistics; RESEARCH funding; BODY mass index; ODDS ratio; RECEIVER operating characteristic curves; LONGITUDINAL method; DISEASE risk factors; PREGNANCY
- Publication
Nutrients, 2023, Vol 15, Issue 11, p2428
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu15112428