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- Title
Improving Tenoxicam Solubility and Bioavailability by Cosolvent System.
- Authors
Yeh, Ming-Kung; Chang, Li-Chien; Chiou, Andy
- Abstract
The formulation study of tenoxicam, a poorly water-soluble drug, was developed by use of a ternary cosolvent system and has significantly enhanced the solubility. Additionally, the relative bioavailability of testing formulation was also evaluated by New Zealand rabbit with a single i.m. injection. The three-phase diagram for dimethylsulfoxide (DMSO)/propylene glycol/water, DMSO/ethanol/water, and DMSO/polyethoxylated castor oil/ethanol system was developed. The volume ratio of 5:4:1 in the DMSO/polyethoxylated castor oil/ethanol system resulted in a more suitable vehicle than other systems, with a high solubility (20.73 mg/ml) and low viscosity (10.0 Cp). A pharmacokinetic study of bioequivalence ( F rel = 0.89) was also obtained. The present study not only provides a novel strategy improving tenoxicam solubility but also helps further scientific knowledge for the development of parenteral formulations.
- Publication
AAPS PharmSciTech, 2009, Vol 10, Issue 1, p166
- ISSN
1530-9932
- Publication type
Article
- DOI
10.1208/s12249-009-9189-2