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- Title
Motivators and barriers of tamoxifen use as risk-reducing medication amongst women at increased breast cancer risk: a systematic literature review.
- Authors
Meiser, B.; Wong, W. K. T.; Peate, M.; Julian-Reynier, C.; Kirk, J.; Mitchell, G.
- Abstract
Background: Selective estrogen receptor modulators, such as tamoxifen, reduce breast cancer risk by up to 50% in women at increased risk for breast cancer. Despite tamoxifen's well-established efficacy, many studies show that most women are not taking up tamoxifen. This systematic literature review aimed to identify the motivators and barriers to tamoxifen use 's amongst high-risk women. Methods: Using MEDLINE, PsycINFO and Embase plus reviewing reference lists of relevant articles published between 1995 and 2016, 31 studies (published in 35 articles) were identified, which addressed high-risk women's decisions about risk-reducing medication to prevent breast cancer and were peer-reviewed primary clinical studies. Results: A range of factors were identified as motivators of, and barriers to, tamoxifen uptake including: perceived risk, breast-cancer-related anxiety, health professional recommendation, perceived drug effectiveness, concerns about side-effects, knowledge and access to information about side-effects, beliefs about the role of risk-reducing medication, provision of a biomarker, preference for other forms of breast cancer risk reduction, previous treatment experience, concerns about randomization in clinical trial protocols and finally altruism. Conclusions: Results indicate that the decision for high-risk women regarding tamoxifen use or non-use as a riskreducing medication is not straightforward. Support of women making this decision is essential and needs to encompass the full range of factors, both informational and psychological.
- Subjects
TAMOXIFEN; ESTROGEN antagonists; BREAST cancer; DISEASES in women; MISOGYNY
- Publication
Hereditary Cancer in Clinical Practice, 2017, Vol 15, p1
- ISSN
1731-2302
- Publication type
Article
- DOI
10.1186/s13053-017-0075-8