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- Title
The landscape of transcriptional profiles in human oocytes with different chromatin configurations.
- Authors
Zhang, Yi-Ran; Yin, Ying; Guo, Shi-Meng; Wang, Yu-Fan; Zhao, Guang-Nian; Ji, Dong-Mei; Zhou, Li-Quan
- Abstract
With increasingly used assisted reproductive technology (ART), the acquisition of high-quality oocytes and early embryos has become the focus of much attention. Studies in mice have found that the transition of chromatin conformation from non-surrounded nucleolus (NSN) to surrounded nucleolus (SN) is essential for oocyte maturation and early embryo development, and similar chromatin transition also exists in human oocytes. In this study, we collected human NSN and SN oocytes and investigated their transcriptome. The analysis of differentially expressed genes showed that epigenetic functions, cyclin-dependent kinases and transposable elements may play important roles in chromatin transition during human oocyte maturation. Our findings provide new insights into the molecular mechanism of NSN-to-SN transition of human oocyte and obtained new clues for improvement of oocyte in vitro maturation technique.
- Subjects
CHROMATIN; OVUM; CYCLIN-dependent kinases; NUCLEOLUS; REPRODUCTIVE technology
- Publication
Journal of Ovarian Research, 2024, Vol 17, Issue 1, p1
- ISSN
1757-2215
- Publication type
Article
- DOI
10.1186/s13048-024-01431-2