We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Pathprinting: An integrative approach to understand the functional basis of disease.
- Authors
Altschuler, Gabriel M.; Hofmann, Oliver; Kalatskaya, Irina; Payne, Rebecca; Ho Sui, Shannan J.; Saxena, Uma; Krivtsov, Andrei V.; Armstrong, Scott A.; Tianxi Cai; Stein, Lincoln; Hide, Winston A.
- Abstract
New strategies to combat complex human disease require systems approaches to biology that integrate experiments from cell lines, primary tissues and model organisms. We have developed Pathprint, a functional approach that compares gene expression profiles in a set of pathways, networks and transcriptionally regulated targets. It can be applied universally to gene expression profiles across species. Integration of large-scale profiling methods and curation of the public repository overcomes platform, species and batch effects to yield a standard measure of functional distance between experiments. We show that pathprints combine mouse and human blood developmental lineage, and can be used to identify new prognostic indicators in acute myeloid leukemia.
- Subjects
DISEASE research; CELL lines; GENE expression; BIOINDICATORS; MYELOID leukemia; PROGNOSIS
- Publication
Genome Medicine, 2013, Vol 5, Issue 7, p1
- ISSN
1756-994X
- Publication type
Article
- DOI
10.1186/gm472