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- Title
C—F Bond Insertion into Indoles with CHBr<sub>2</sub>F: An Efficient Method to Synthesize Fluorinated Quinolines and Quinolones.
- Authors
Li, Chao; Chen, Lei; Wang, Hongye; Yan, Zixi; Lyu, Bin; Lyu, Weiping; Jiang, Changwei; Lu, Dehua; Li, Jiaxing; Jiao, Ning; Song, Song
- Abstract
Comprehensive Summary: A mild and practical method for synthesizing fluorinated quinoline derivatives, which have a wide range of applications in pharmaceuticals, materials, and organic synthesis, was described through C—F bond insertion into indoles using CHBr2F. The simple conditions, readily availability of CHBr2F, as well as the versatility of the transformations make this strategy very powerful in synthesizing 3‐fluoroquinoline and 3‐fluoroquinolone. The mechanistic studies reveal that bromofluorocarbene generated in‐situ under basic condition was the key intermediate.
- Subjects
FLUOROQUINOLONES; QUINOLINE derivatives; INDOLE compounds; ORGANIC synthesis; QUINOLINE; INDOLE derivatives
- Publication
Chinese Journal of Chemistry, 2024, Vol 42, Issue 10, p1128
- ISSN
1001-604X
- Publication type
Article
- DOI
10.1002/cjoc.202400033