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- Title
A Novel Dual Channel Fluorescent Probe for Ca<sup>2+</sup> and Zn<sup>2+</sup> Based on a Coumarin Schiff Base.
- Authors
Pan, Shengnan; Tang, Haoyang; Song, Zhanke; Li, Jin; Guo, Yuan
- Abstract
A novel coumarin Schiff base fluorescent probe ethyl 7-hydroxycoumarin-3-carboxylate-8-formaldehyde benzoyl hydrazone ( EBH) has been designed and synthesized which shows solvent dependent dual sensing, viz., recognition of Ca2+ in DMF-H2O (9∶1, V/ V) solution based on C = N isomerization, photoinduced electron transfer ( PET) inhibition and chelation-enhanced fluorescence ( CHEF) mechanism as well as detection of Zn2+ in H2O-CH3OH (9∶1, V/ V) solution by excited-state intramolecular proton transfer ( ESIPT) and CHEF processes. The structure of the probe EBH has been confirmed by single-crystal X-ray diffraction analysis. Meanwhile, the probe was also used to image intracellular Zn2+ ions in MCF-7 cells with a good performance.
- Subjects
FLUORESCENT probes; CALCIUM ions; ZINC ions; SCHIFF bases; HYDRAZONES
- Publication
Chinese Journal of Chemistry, 2017, Vol 35, Issue 8, p1263
- ISSN
1001-604X
- Publication type
Article
- DOI
10.1002/cjoc.201600923