We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Altered mean platelet volume in children with Henoch-Schonlein purpura and its association with disease activity.
- Authors
Xiang Shi; Wen-Chao Li; Li-Jun Mo; Xiao-Hong Li; Yu-Zhen Luo; Liu-Qun Qin; Zheng Yang; Wu-Ning Mo; Shi, Xiang; Li, Wen-Chao; Mo, Li-Jun; Li, Xiao-Hong; Luo, Yu-Zhen; Qin, Liu-Qun; Yang, Zheng; Mo, Wu-Ning
- Abstract
Background Henoch-Schonlein purpura is a systemic small-vessel vasculitis that occurs mainly in children. A review of the literature has suggested a correlation between mean platelet volume and several inflammatory disorders. However, to the best of our knowledge, any potential correlation between mean platelet volume and Henoch-Schonlein purpura has not been reported in the literature. Therefore, our study aimed to evaluate the role of mean platelet volume concentrations in patients with Henoch-Schonlein purpura. Methods This study included 97 children with Henoch-Schonlein purpura and 120 healthy individuals as controls. Results Mean platelet volume concentrations were found to be significantly lower in Henoch-Schonlein purpura patients compared with healthy controls (8.1 ± 0.86 vs. 9.4 ± 0.81, P < 0.001). Similarly, significant negative correlations were observed between mean platelet volume and neutrophil count, platelet count and erythrocyte sedimentation rate in patients with Henoch-Schonlein purpura (r=-0.327, P = 0.001; r=-0.419, P < 0.001; r=-0.255, P = 0.012). Interestingly, mean platelet volume was significantly lower in the acute phase compared with the convalescent phase of Henoch-Schonlein purpura patients (7.8 ± 0.86 vs. 8.3 ± 0.77, P = 0.002). A cut-off value for mean platelet volume was 7.85 with area under the curve of 0.726 to identify acute phase vs. convalescent phase in patients with Henoch-Schonlein purpura. Mean platelet volume was independently associated with Henoch-Schonlein purpura in logistic regression analysis (odds ratio = 0.114, 95% confidence interval = 0.053-0.243, P < 0.001). Conclusions Our results suggest that mean platelet volume is inversely associated with disease in patients with Henoch-Schonlein purpura, and mean platelet volume may be a useful marker to identify active disease in Henoch-Schonlein purpura patients.
- Subjects
BLOOD platelets; VASCULITIS; ERYTHROCYTES; PLATELET count; NEUTROPHILS; CONFIDENCE intervals; LOGISTIC regression analysis; SYMPTOMS; CONTROL groups; SCHOENLEIN-Henoch purpura; MEAN platelet volume; ODDS ratio; CHILDREN
- Publication
Annals of Clinical Biochemistry, 2018, Vol 55, Issue 3, p368
- ISSN
0004-5632
- Publication type
journal article
- DOI
10.1177/0004563217727015