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- Title
Preterm Glycosuria – New Data from a Continuous Glucose Monitoring System.
- Authors
Jagła, Mateusz; Szymońska, Izabela; Starzec, Katarzyna; Kwinta, Przemko
- Abstract
<bold><italic>Background:</italic></bold> Careful control of glucose homeostasis is essential for infants with very low birth weight (VLBW). In clinical practice, blood and urine glucose levels are monitored; however, their correlation has not been fully investigated in VLBW infants. <bold><italic>Objectives:</italic></bold> To evaluate the correlation between interstitial fluid glucose concentration (ISFG), glycosuria, and urine output among VLBW infants through continuous glucose monitoring (CGM). <bold><italic>Methods:</italic></bold> A prospective, single-center, open cohort study enrolled 74 VLBW infants with a mean birth weight of 1,066 g. CGM (Guardian Real-Time CGM®; Medtronic, Northridge, CA, USA) was used to measure glucose. The urine output was calculated using 4-hour intervals. Reagent strips were used for semiquantitative measurement of glycosuria. <bold><italic>Results:</italic></bold> The CGM delivered 102,334 glucose measurements. 2,684 urine samples were checked for glycosuria, of which 92.06% remained negative. Corresponding glycemia in samples without glycosuria remained normoglycemic (median 103 mg/dL; 10–90th percentile 80–144 mg/dL). The median glucose concentrations for samples in ascending glycosuria categories 1+, 2+, 3+, and 4+ were 152, 181, 214, and 222 mg/dL, respectively. A moderate correlation between ISFG and urine output was found for categories ≥1+ (<italic>r</italic><italic>s</italic> = 0.56; 95% confidence interval 0.42–0.68; <italic>p</italic> < 0.001). The urine output was significantly lower when glycosuria was absent (<italic>p</italic> < 0.05). Polyuria was observed only in glycosuria 4+ (median urine output 9.9; interquartile range 7.4–12.2 mL/kg/h). <bold><italic>Conclusions:</italic></bold> The renal glucose threshold in VLBW infants is between 150 and 180 mg/dL. A negative result for glycosuria is a reliable screening test to exclude hyperglycemia. Occurrence of glycosuria ≥1+ is an indication to test blood glucose.
- Subjects
HOMEOSTASIS; GLYCOSURIA; HYPERGLYCEMIA
- Publication
Neonatology (16617800), 2018, Vol 114, Issue 1, p87
- ISSN
1661-7800
- Publication type
Article
- DOI
10.1159/000487846