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- Title
Validated RP-HPLC Method for Analysis of Aripiprazole in a Formulation.
- Authors
Kalaichelvi, R.; Thangabalan, B.; Rao, D. Srinivasa
- Abstract
A rapid, simple and validated reversed-phase high-performance liquid chromatographic method has been developed for analysis of aripiprazole in tablet dosage form. Aripiprazole was separated on an ODS analytical column with a 40:60 (v/v) mixture of acetonitrile and triethanolamine buffer (5 mM, pH 3.5 ± 0.05 adjusted by addition of 85% phosphoric acid) as mobile phase at a flow rate of 1.5 mL min-1. The effluent was monitored by UV detection at 254 nm. Calibration plots were linear in the range of 20 to 60 μg mL-1 and the LOD and LOQ were 0.411 and 1.248 μg mL-1, respectively. The high recovery and low relative standard deviation confirm the suitability of the method for routine quality control determination of aripiprazole in tablets.
- Subjects
HIGH performance liquid chromatography; DRUG dosage; STANDARD deviations; QUALITY control; ACETONITRILE; ULTRAVIOLET radiation; STANDARDIZATION; PHOSPHORIC acid; CAPILLARY electrophoresis
- Publication
E-Journal of Chemistry, 2010, Vol 7, Issue 3, p827
- ISSN
0973-4945
- Publication type
Article
- DOI
10.1155/2010/935279