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- Title
Strategies to enhance nasopharyngeal carcinoma screening in patients with adult‐onset idiopathic inflammatory myopathies.
- Authors
Tang, Iris Y. K.; Li, Teresa W. L.; Luk, Lucas T. H.; Ho, Brian; Ho, Roy; Lai, Billy T. L.; Lee, Patrick M. L.; So, Ho
- Abstract
This article explores strategies to improve screening for nasopharyngeal carcinoma (NPC) in patients with adult-onset idiopathic inflammatory myopathies (IIM). IIM is a group of autoimmune diseases characterized by muscle inflammation and other manifestations. The study emphasizes the strong link between NPC and IIM in East and Southeast Asian populations and suggests nasoendoscopy (NE) at IIM diagnosis in regions with high NPC prevalence. The article also discusses the prevalence of NPC among IIM patients in the Asia Pacific region and proposes methods to enhance NPC detection. Additionally, the document summarizes the characteristics of IIM patients with NPC, highlighting higher mortality rates in this group but suggesting better survival when NPC is detected early. The study recommends a stratified cancer screening approach for NPC detection in at-risk IIM populations, including repeated NE, blind biopsy, additional imaging, and plasma EBV-DNA detection as potential screening options.
- Subjects
MYOSITIS; DERMATOMYOSITIS; NASOPHARYNX cancer; MEDICAL screening; IDIOPATHIC diseases; POSITRON emission tomography computed tomography; MUSCLE diseases
- Publication
International Journal of Rheumatic Diseases, 2024, Vol 27, Issue 6, p1
- ISSN
1756-1841
- Publication type
Article
- DOI
10.1111/1756-185X.15215