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- Title
Photophysical, Cellular-Uptake, and Bioimaging Studies of Luminescent Ruthenium(II)-Polypyridine Complexes Containing a d-Fructose Pendant.
- Authors
Lau, Chris Tsan‐Shing; Chan, Christina; Zhang, Kenneth Yin; Roy, Vellaisamy A. L.; Lo, Kenneth Kam‐Wing
- Abstract
Two luminescent ruthenium(II)-polypyridine complexes, appended with a d-fructose unit, [Ru(N^N)2(bpy-fructose)](PF6)2 [bpy-fructose = 4-(1-deoxy- d-fructos-1-yl)aminocarbonyl-4′-methyl-2,2′-bipyridine; N^N = 4,7-diphenyl-1,10-phenanthroline (Ph2-phen) ( 1a) and 2,2′-bipyridine (bpy) ( 2a)] and their d-fructose-free counterparts [Ru(N^N)2(bpy-Et)](PF6)2 [bpy-Et = 4-(ethylaminocarbonyl)-4′-methyl-2,2′-bipyridine; N^N = Ph2-phen ( 1b) and bpy ( 2b)] are synthesized and characterized. The photophysical properties, lipophilicity, cytotoxicity, and cellular uptake of the complexes are studied. Laser-scanning confocal microscopy reveals that both complexes 1a and 1b display intense membrane staining toward human breast adenocarcinoma (MCF-7) cells. However, while complex 1a retains its membrane-staining characteristic when incubated with human cervical epithelioid carcinoma (HeLa) cells, complex 1b is localized in the mitochondria. Additionally, fructose-dependent cellular-uptake experiments suggest that complex 1a is transported into MCF-7 cells through a glucose transporter (GLUT) mediated pathway.
- Subjects
LUMINESCENCE; RUTHENIUM compounds; POLYPYRIDINES; METAL complexes; FRUCTOSE
- Publication
European Journal of Inorganic Chemistry, 2017, Vol 2017, Issue 44, p5288
- ISSN
1434-1948
- Publication type
Article
- DOI
10.1002/ejic.201701038