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- Title
Hemophagocytic syndrome in a cat with immune‐mediated hemolytic anemia.
- Authors
Tagawa, Michihito; Aoki, Minori; Uemura, Akiko; Yanagawa, Masashi; Mineshige, Takayuki; Watanabe, Ken‐ichi; Kobayashi, Yoshiyasu
- Abstract
A 10‐year‐old spayed female domestic short‐haired cat presented with depression, anorexia, and tachypnea. A complete blood count revealed moderate regenerative anemia, severe leukopenia, and mild thrombocytopenia. Antibodies against feline immunodeficiency virus (FIV) were also detected. Abdominal radiography and ultrasonography revealed severe splenomegaly. Cytologic evaluation of the spleen revealed macrophagic infiltration with hemophagocytosis. Bone marrow aspiration revealed erythroid hyperplasia with no other abnormalities. A presumptive diagnosis of hemophagocytic syndrome secondary to immune‐mediated hemolytic anemia was made based on a positive direct Coombs test result. Blood transfusion, prednisolone, and immunosuppressive treatments were performed; however, the blood abnormalities did not improve. The cat was then administered prednisolone and chlorambucil, followed by splenectomy. Leukopenia immediately recovered, and packed cell volume increased slightly. However, the blood abnormalities recurred, and the cat died. To the best of our knowledge, this is the first report of hemophagocytic syndrome secondary to immune‐mediated disease in an FIV‐positive cat.
- Subjects
HEMOPHAGOCYTIC lymphohistiocytosis; HEMOLYTIC anemia; FELINE immunodeficiency virus; BLOOD cell count; CELL size; PHAGOCYTOSIS; HEMORHEOLOGY; BONE marrow; CAT diseases
- Publication
Veterinary Clinical Pathology, 2023, Vol 52, Issue 2, p313
- ISSN
0275-6382
- Publication type
Article
- DOI
10.1111/vcp.13176