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- Title
Cellular Abnormalities and Emerging Biomarkers in Alcohol-Associated Liver Disease.
- Authors
Singal, Ashwani K.; Bailey, Shannon M.
- Abstract
Alcohol-associated liver disease (AALD) is the third most common preventable cause for disease burden and mortality in the US. AALD, including alcoholic hepatitis (AH), contributes to half of admissions from decompensated liver disease and 20% of all liver transplants in the US. Peripheral blood cells contribute to systemic inflammation, oxidative stress, mitochondrial dysfunction, and fibrosis in AALD and AH. Alcohol dysregulates function of lymphocytes, neutrophils, monocytes, and tissue macrophages of the innate immune system. These alterations in turn can modulate adaptive immune responses. In this review, we describe these disruptive effects of alcohol on cells of the innate and adaptive immune system and focus on cellular-based emerging biomarkers on diagnosis and prognosis of patients with AALD and AH.
- Subjects
LIVER regeneration; INFLAMMATION; MACROPHAGES; NATURAL immunity; ALCOHOLIC liver diseases
- Publication
Gene Expression (1052-2166), 2018, Vol 19, Issue 1, p49
- ISSN
1052-2166
- Publication type
Article
- DOI
10.3727/105221618X15325235888914