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- Title
Synthesis and Characterization of a Dinuclear Copper Complex Bearing a Hydrophobic Cavity as a Model for Copper-Containing Monooxygenases.
- Authors
Schicke, Olivier; Faure, Bruno; Carissan, Yannick; Giorgi, Michel; Jalila Simaan, Ariane; Réglier, Marius
- Abstract
The synthesis and characterization of a dinuclear copper complex as a model of mononuclear copper-containing monooxygenases [dopamine β-monooxygenase (DβM), tyramine β-monooxygenase (TβM), and peptidylglycine α-hydroxylating monooxygenase (PHM)] are described. This model is based on a cyclophane moiety bearing two bis(picolylamine) ligands for the complexation of two copper atoms and exhibits macroscopic features equivalent to those of the enzymes: (1) the two copper centers are 11.5 Å apart (11 Å for the enzymes) and (2) there is a hydrophobic pocket consisting of a cyclophane moiety in which substrates can bind near the two copper centers.
- Subjects
COPPER compounds synthesis; MONOOXYGENASES; COPPER; PEPTIDYLGLYCINE monooxygenase; CYCLOPHANES; FUNCTIONAL groups; PICOLYLAMINES
- Publication
European Journal of Inorganic Chemistry, 2015, Vol 2015, Issue 21, p3512
- ISSN
1434-1948
- Publication type
Article
- DOI
10.1002/ejic.201500280