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- Title
Simply better glycoproteins.
- Authors
Lepenies, Bernd; Seeberger, Peter H
- Abstract
The authors discuss the paper by L. Meuris and colleagues regarding the use of an elegant method called GlycoDelete to reduce N-glycan heterogeneity of recombinant glycoproteins in mammalian cells. They mention that the authors performed manipulation to the glycosylation machinery in the Golgi apparatus. They state that the method may be feasible for the manipulation of enzymes in Golgi does not interfere with the quality mediated by N-glycan in the endoplasmic reticulum.
- Subjects
MEURIS, L.; GLYCANS; GLYCOPROTEINS; RECOMBINANT proteins; GLYCOSYLATION; GOLGI apparatus
- Publication
Nature Biotechnology, 2014, Vol 32, Issue 5, p443
- ISSN
1087-0156
- Publication type
Article
- DOI
10.1038/nbt.2893