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- Title
SIGNAL TRANSDUCERS AND ACTIVATORS OF TRANSCRIPTION: INSIGHTS INTO THE MOLECULAR BASIS OF ORAL CANCER.
- Authors
Siavash, H.; Nikitakis, N. G.; Sauk, J. J.
- Abstract
Recent efforts on developing more direct and effective targets for cancer therapy have revolved around a family of transcription factors known as STATs (signal transducers and activators of transcription). STAT proteins are latent cytoplasmic transcription factors that become activated in response to extracellular signaling proteins. STAT proteins have been convincingly reported to possess oncogenic properties in a plethora of human cancers, including oral and oropharyngeal cancer. Signal transduction pathways mediated by these oncogenic transcription factors and their regulation in oral cancer are the focus of this review.
- Subjects
SQUAMOUS cell carcinoma; ORAL cancer; CELLULAR signal transduction; GENETIC transcription regulation; ONCOGENES; MOLECULAR oncology
- Publication
Critical Reviews in Oral Biology & Medicine, 2004, Vol 15, Issue 5, p298
- ISSN
1045-4411
- Publication type
Article
- DOI
10.1177/154411130401500505