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- Title
Predictors of mucositis in oropharyngeal and oral cavity cancer in patients treated with volumetric modulated radiation treatment: A dose-volume analysis.
- Authors
Mazzola, Rosario; Ricchetti, Francesco; Fersino, Sergio; Fiorentino, Alba; Giaj Levra, Niccolò; Di Paola, Gioacchino; Ruggieri, Ruggero; Alongi, Filippo
- Abstract
Background The purpose of this study was to assess predictors of mucositis in oropharyngeal and oral cavity cancer after definitive or adjuvant volumetric modulated arc radiotherapy (VMAT) +/− chemotherapy. Methods Fifty patients were evaluated. Statistical analysis was performed for the following parameters as potential predictors of mucositis ≥ G2: total oral mucosa and oral mucosa minus target high-low radiation dose regions (planning target volumes [PTVs]), mean dose (Dmean), maximum dose (Dmax), chemotherapy, weight loss, and dysphagia. Results Mucositis ≥ G2 was found to be statistically related to chemotherapy, weight loss, dysphagia ≥ G2, total oral mucosa Dmean ≥50 Gy and Dmax ≥65 Gy, V45 Gy >40%, V50 Gy >30%, and V55 Gy >20% of the oral mucosa minus target PTVs. A ratio between total oral mucosa and oral mucosa minus target PTVs >2.5 is related to G3 mucositis ( p = .03). Conclusion New parameters were found as predictors of moderate-severe mucositis. © 2015 Wiley Periodicals, Inc. Head Neck 38: E815-E819, 2016
- Subjects
MUCOSITIS; OROPHARYNGEAL cancer; TREATMENT of oral cancer; CANCER radiotherapy research; CANCER chemotherapy
- Publication
Head & Neck, 2016, Vol 38, pE815
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.24106