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- Title
Long-term experience with reduced planning target volume margins and intensity-modulated radiotherapy with daily image-guidance for head and neck cancer.
- Authors
Chen, Allen M.; Yu, Yao; Daly, Megan E.; Farwell, D. Gregory; H. Benedict, Stanley; Purdy, James A.
- Abstract
Background The purpose of this study was to compare outcomes among patients treated by intensity-modulated radiotherapy (IMRT) with daily image-guided radiotherapy (IGRT) for head and neck cancer according to the margins used to expand the clinical target volume (CTV) to create a planning target volume (PTV). Methods Three hundred sixty-seven consecutive patients were treated with IMRT for squamous cell carcinoma of the head and neck. The first 103 patients were treated with 5-mm CTV-to-PTV margins. The subsequent 264 patients were treated using reduced (3 mm) margins. Results The 3-year locoregional control for patients treated using 5-mm and 3-mm CTV-to-PTV margins, respectively, was 78% and 80% ( p = .75). The incidence of gastrostomy-tube dependence at 1 year was 10% and 3%, respectively ( p = .001). The incidence of posttreatment esophageal stricture was 14% and 7%, respectively ( p = .01). Conclusion The use of reduced (3 mm) CTV-to-PTV margins was associated with reduced late toxicity while maintaining locoregional control. © 2014 Wiley Periodicals, Inc. Head Neck 36: 1766-1772, 2014
- Subjects
SQUAMOUS cell carcinoma; RADIOTHERAPY; HEAD &; neck cancer; CANCER treatment
- Publication
Head & Neck, 2014, Vol 36, Issue 12, p1766
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.23532