We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Synthesis and antitumor activity of 3-arylisoquinoline derivatives.
- Authors
Cho, Won-Jea; Yoo, Su-Jeong; Park, Myun-Ji; Chung, Byung-Ho; Lee, Chong-Ock
- Abstract
In order to study the structure-activity relationship of 7,8-dimethoxy-2-methyl-3-(4,5-methylen-edioxy-2-vinylphenyl)isoquinoline-1 ( 2H)-one ( 2), which has exhibited significant antitumor activity, chemical modifications of 2 were performed to yield the corresponding products ( 3–7). Further systematic uses of an efficient procedure for the synthesis of 3-arylisoquinoline derivatives produced the substituted compounds ( 9a−9g), which were tested for in vitro antitumor activity against five different human cancer cell lines.
- Publication
Archives of Pharmacal Research, 1997, Vol 20, Issue 3, p264
- ISSN
0253-6269
- Publication type
Article
- DOI
10.1007/BF02976155