We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Mismatch Repair Deficiency Screening via Immunohistochemical Staining in Young Asians with Colorectal Cancers.
- Authors
Chew, Min-Hoe; Koh, Poh-Koon; Tan, Melinda; Lim, Kiat-Hon; Carol, Loi; Tang, Choong-Leong
- Abstract
Background: The incidence of mismatch repair deficiency in colorectal cancer (CRC) in young people remains unknown in Asians. The present study assessed the clinicopathological features and efficacy of immunohistochemistry screening for Lynch syndrome in young Asian CRC patients. Material and methods: This was a retrospective review conducted in Singapore General Hospital between January 2006 and December 2010 of 240 unrelated patients under the age of 50. All patients had immunohistochemical (IHC) staining for mismatch repair proteins in resected CRC specimen data retrieved from a prospective computerized database. Results: A total of 21 % ( n = 51) of the patients had abnormal IHC staining. Loss of staining for MLH1, MSH2, MSH6, and PMS2 proteins was observed in 10, 4, 6, and 13 % of tumors, respectively. Of the 22 patients who had abnormal staining of MLH1, 13 had concomitant abnormal staining for PMS2. One tumor specimen had abnormal staining in all four proteins. If the Amsterdam criteria alone were to be used, 86 % ( n = 44) of the cohort would have not been detected for mismatch repair gene defects. Conclusions: The overall burden of germline mismatch repair deficiency in the Singapore population may be as high as 21 %. The Amsterdam criteria alone are inadequate to detect Lynch syndrome patients. The use of IHC staining of at least four mismatch repair proteins is a useful screening strategy for Lynch syndrome diagnosis. Routine screening of mismatch repair deficiency may be recommended for all young Asian CRC patients.
- Subjects
COLON cancer patients; IMMUNOHISTOCHEMISTRY; ASIANS; MEDICAL screening; LYNCH syndrome II; DISEASES
- Publication
World Journal of Surgery, 2013, Vol 37, Issue 10, p2468
- ISSN
0364-2313
- Publication type
Article
- DOI
10.1007/s00268-013-2134-2