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- Title
Oral misoprostol in the third stage of labor
- Authors
Zachariah, E.S.; Naidu, M.; Seshadri, L.
- Abstract
<bold>Objective: </bold>To compare the efficacy of intravenous ergometrine, intramuscular oxytocin, and oral misoprostol in the control of postpartum hemorrhage.<bold>Methods: </bold>Mean blood loss, rates of blood loss between 500 and 1000 ml, hematocrit fall greater than 10%, and need for additional oxytocic agents and nature and rates of adverse effects were assessed in this prospective, randomized, controlled study.<bold>Results: </bold>All outcomes were similar in the 3 groups. The main adverse effects in the misoprostol group were temperatures higher than 99 degrees F, which normalized within 2 h and shivering, which was mild and self-limiting.<bold>Conclusions: </bold>Oral misoprostol is as effective as conventional oxytocic agents in preventing postpartum hemorrhage and can be recommended for use in low-resource settings.
- Subjects
PUERPERAL disorders; ARTERIAL injuries; BLOOD testing; HEMORRHAGE; HEMORRHAGE prevention; COMPARATIVE studies; INTRAMUSCULAR injections; INTRAVENOUS injections; LABOR (Obstetrics); LONGITUDINAL method; RESEARCH methodology; MEDICAL cooperation; ORAL drug administration; OXYTOCIN; RESEARCH; EVALUATION research; RANDOMIZED controlled trials; TREATMENT effectiveness; MISOPROSTOL; OXYTOCICS; ERGOMETRINE; PREVENTION
- Publication
International Journal of Gynecology & Obstetrics, 2006, Vol 92, Issue 1, p23
- ISSN
0020-7292
- Publication type
journal article
- DOI
10.1016/j.ijgo.2005.08.026