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- Title
Prevalence of carotid stenosis following radiotherapy for head and neck cancer: A systematic review and meta‐analysis.
- Authors
Texakalidis, Pavlos; Giannopoulos, Stefanos; Tsouknidas, Ioannis; Song, Shiyu; Rivet, Dennis J.; Reiter, Evan R.; Reavey‐Cantwell, John
- Abstract
Background: Radiation to the head and neck is a well‐established risk factor for the development of carotid artery stenosis. Our objective was to identify the prevalence, incidence, and degree of carotid stenosis in patients with a history of head and neck irradiation. Methods: This study was performed according to the PRISMA guidelines. A random effects model meta‐analysis was conducted. Results: Nineteen studies comprising 1479 patients were included. The prevalence of carotid stenosis >50%, >70%, and carotid occlusion was 25% (95% CI: 19%‐32%), 12% (95% CI: 7%‐17%), and 4% (95% CI: 2%‐8%), respectively. The cumulative 12‐month incidence of carotid stenosis >50% was 4% (95% CI: 2%‐5%), the 24‐month was 12% (95% CI: 9%‐15%), and the 36‐month was 21% (95% CI: 9%‐36%). Conclusions: The yearly incidence of carotid stenosis >50% increased every year during the first 3 years following radiotherapy. We propose routine yearly Doppler ultrasound screening beginning 1 year after head and neck radiotherapy.
- Subjects
CAROTID artery stenosis; HEAD &; neck cancer; META-analysis; RANDOM effects model; BACKGROUND radiation
- Publication
Head & Neck, 2020, Vol 42, Issue 5, p1077
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.26102