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- Title
INTERLEUKIN (IL) 12, IL-23 AND IL-23 RECEPTOR IN ANKYLOSING SPONDYLITIS PATHOPHYSIOLOGY INTERLEUKIN (IL) 12, IL-23 AND IL-23 RECEPTOR IN ANKYLOSING SPONDYLITIS PATHOPHYSIOLOGY.
- Authors
Cherciu, Marius; Cherciu, Laura Ioana; Bojinca, Mihai; Serban, Teodora; Bara, Constantin; Popa, Olivia Mihaela
- Abstract
Ankylosing spondylitis (AS) is a chronic infl ammatory arthritis which involves mainly the spine and the sacroiliac joints, but also the peripheral joints and nonarticular structures. IL-12 and IL-23 are heterodimeric cytokines sharing a common p40 subunit. Studies showed than IL-12 is essential for Th1 differentiation while IL-23 promotes a particular subset of T cells characterized by IL-17 production, called Th17. Since the association of IL-23R with AS was reported, the scientifi c interest has focused on identifying new single nucleotide polymorphisms (SNPs), present in the coding genes for IL-12/IL-23 subunits and their receptors, that increase the susceptibility for AS. Another point of interest for researchers was to investigate if the identifi ed gene variants modify the gene expression of the respective interleukins and/or their receptors, whether that refers to their mRNA expression, their serum levels or the expression of the receptors on the surface of T cells. Given the increasing amount of data that suggests the pivotal role of the IL-23/Th17 axis in AS pathophysiology, new promising therapies, designed to interfere with these pathways, are now in development.
- Subjects
INTERLEUKIN receptors; ANKYLOSING spondylitis; PATHOLOGICAL physiology; SACROILIAC joint diseases; NONARTICULAR rheumatism; TH1 cells; CELL differentiation
- Publication
Romanian Journal of Rheumatology / Revista Romana de Reumatologie, 2015, Vol 24, Issue 1, p5
- ISSN
1843-0791
- Publication type
Article
- DOI
10.37897/rjr.2015.1.1