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- Title
Upregulated Pdx1 and MafA Contribute to β-Cell Function Improvement by Sleeve Gastrectomy.
- Authors
Li, Feng; Cao, Han; Sheng, Chunjun; Sun, Hang; Song, Kexiu; Qu, Shen
- Abstract
Purpose: Sleeve gastrectomy is an effective technique for the treatment of severe obesity, and its effects on the improved β-cell function have not yet been fully understood. Materials and Methods: From February 2014 to July 2015, sleeve gastrectomy was performed in 5 patients with T2D, who were assessed before and after sleeve gastrectomy (SG). Moreover, a high-fat-diet (HFD) mouse model was also used to study the molecular mechanisms of β-cell functional improvement after SG. Results: The glucose-stimulated acute insulin response was restored in the T2D patients after SG. The expression of GLP-1 in colonic tissue as well as β-cell specific transcription factors (TFs), Pdx1, and MafA in islets was significantly increased after SG. Conclusion: β-cell dysfunction can be ameliorated by SG. The re-activation of key TFs contributes to the improvement of β cell function.
- Subjects
CELL physiology; GASTRECTOMY; OBESITY treatment; HIGH-fat diet; LABORATORY mice
- Publication
Obesity Surgery, 2016, Vol 26, Issue 4, p904
- ISSN
0960-8923
- Publication type
Article
- DOI
10.1007/s11695-016-2068-5