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- Title
Hematological and Biochemical Changes in Male Patients with Thalassemia Major.
- Authors
Arshad, Bushra; Iqbal, Tahira; Jamil, Amer; Hasan, Ijaz Javed
- Abstract
The present study reports the hematological and biochemical parameters in β-thalassemia patients with transfusional iron overload and chelation therapy. Fifty βthalassemia major male patients and fifty healthy male subjects were selected form Punjab, Pakistan. The t-value of studied hematological parameters were as follows: red blood cell count (127.9, P<0.00), platelet count (52.02, P<0.00), mean corpuscular volume (28.19, P<0.00l), mean corpuscular hemoglobin (58.42, P<0.00), neutrophils (4.05, P<0.001), mean corpuscular hemoglobin concentration (44.86, P<0.00), hemoglobin (79.8, P<0.001), monocytes (294.5, P<0.00), lymphocytes (32.28, P<0.001), hematocrit value (120.3, P<0.00), total leukocyte count (11.03, P<0.001), eosinophils (21.34, P<0.000) and erythrocyte sedimentation rate (286.8, P<0.00). The biochemical parameters were as follows: alanine aminotransferase (88.22, P<0.00), aspartate aminotransferase (86.95, P<0.00), urea (20.82, P<0.00), total protein (31.17, P<0.001), albumin (11.31,P<0.00), globulin (20.06, P0.001), triglyceride (72.21, P0.001), Cholesterol (55.78,P<0.00), high density lipoproteins (46.28, P<0.00), low density lipoproteins (71.03, P<0.00) and ferritin (934.7, P<0.00O). Statistically highly significant difference was detected for these parameters. The lower level of RBCs, Hb, HCT, MCHC, MCV, RDW, MCH, Creatinine and HDL were found in beta thalassemic male patients and higher leve! of liver enzymes (ALT, AST), ferritin, TG, cholesterol, LDL and urea were observed in thalassemic patients than healthy volunteers. The hematological and biochemical profiles were significantly altered in thalassemic patients as compared to healthy individuals. All these disturbances are linked with severe anemia, βglobin chain lysis, blood transfusions, accumulation of α-chains and elevated free iron contents. Based upon findings of the present study, it can be suggested that blood biochemistry parameters should be considered necessary for better therapeutic protocol to recommend proper blood transfusion with supplementation of antioxidant vitamins, dose and frequency of chelating drug for patients of beta thalassemia.
- Subjects
HEMATOLOGY; THALASSEMIA; BIOCHEMISTRY; HEMATOCRIT; SEDIMENTATION &; deposition; ALANINE aminotransferase
- Publication
Pakistan Journal of Life & Social Sciences, 2014, Vol 12, Issue 1, p31
- ISSN
1727-4915
- Publication type
Article