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- Title
A prospective study of serum ghrelin levels in patients treated with clozapine.
- Authors
Theisen, F. M.; Gebhardt, S.; Brömel, T.; Otto, B.; Heldwein, W.; Heinzel-Gutenbrunner, M.; Krieg, J.-C.; Remschmidt, H.; Tschöp, M.; Hebebrand, J.
- Abstract
We investigated serum ghrelin levels (SGL) in 12 patients with schizophrenia over a 10-week period after initiation of clozapine treatment. In contrast to increments of body mass indices (BMI, kg/m2) and serum leptin levels (SLL), no significant change in SGL was detected. Inverse correlations between delta SGL and delta SLL did not reach statistical significance. Linear mixed model analysis could not detect effects of age, sex, BMI, SLL and serum clozapine levels on SGL. Our results do not support a causal involvement of ghrelin in clozapine-related weight gain.
- Subjects
BLOOD plasma; CLOZAPINE; ANTIDEPRESSANTS; BODY weight; SCHIZOPHRENIA; WEIGHT gain; LEPTIN
- Publication
Journal of Neural Transmission, 2005, Vol 112, Issue 10, p1411
- ISSN
0300-9564
- Publication type
Article
- DOI
10.1007/s00702-005-0284-6