We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
MAGI-2 Is a Sensitive and Specific Marker of Prostatic Adenocarcinoma: A Comparison With AMACR.
- Authors
Goldstein, Jeffery; Goyal, Rajen; Roland, Joseph T.; Gellert, Lan L.; Clark, Peter E.; Hameed, Omar; Giannico, Giovanna A.
- Abstract
<bold>Objectives: </bold>We compared the utility of membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (MAGI-2) and α-methylacyl CoA (AMACR) by immunohistochemistry in diagnosing prostatic adenocarcinoma.<bold>Methods: </bold>Seventy-eight radical prostatectomies were used to construct three tissue microarrays with 512 cores, including benign prostatic tissue, benign prostatic hyperplasia, high-grade prostatic intraepithelial neoplasia (HGPIN), and adenocarcinoma. AMACR and MAGI-2 immunohistochemistry were evaluated by visual and image analysis.<bold>Results: </bold>MAGI-2 and AMACR were significantly higher in adenocarcinoma and HGPIN compared with benign tissue. At H-score cutoffs of 300 and 200, MAGI-2 was more accurate in distinguishing benign from malignant glands than AMACR. Areas under the curve by image and visual analysis were 0.846 and 0.818 for MAGI-2 and 0.937 and 0.924 for AMACR, respectively. The accuracy of MAGI-2 in distinguishing benign from malignant glands on the same core was higher (95% vs 88%).<bold>Conclusions: </bold>MAGI-2 could represent a useful adjunct for diagnosis of prostatic adenocarcinoma, especially when AMACR is not discriminatory.
- Subjects
KINASES; ADENOCARCINOMA; COENZYME A; IMMUNOHISTOCHEMISTRY; DIAGNOSIS
- Publication
American Journal of Clinical Pathology, 2016, Vol 146, Issue 3, p294
- ISSN
0002-9173
- Publication type
journal article
- DOI
10.1093/ajcp/aqw111