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- Title
Mesothelin Expression in Pancreatic Mucinous Cysts.
- Authors
Frank, Renee; Shaoying Li; Ahmad, Nuzhat A.; Sepulveda, Antonia R.; Jhala, Nirag C.
- Abstract
Objectives: Mesothelin (MSLN) is a differentiation antigen found to be overexpressed in intraductal papillary mucinous neoplasms (IPMNs) and is a potential treatment target in pancreatic ductal adenocarcinoma. Methods: From institutional archives, 114 cases of resected pancreatic mucinous cysts were identified, including IPMN and mucinous cystic neoplasm (MCN). Immunohistochemical analysis of MSLN was performed on representative sections. Results: MSLN was seen more frequently in neoplastic epithelial cells from IPMN (39/52; P < .0005) and MCN (9/14; P < .0001) compared with unremarkable adjacent pancreatic and bile ducts (0/57) and benign foveolar and duodenal epithelium (0/21). When present, MSLN was diffusely expressed in neoplastic epithelium and only focally expressed in adjacent ducts (8/57). No significant difference was seen (P = .26) in MLSN expression between IPMN (79%) and MCN (83%) when only presence or absence was considered. Conclusion: Our findings suggest that MLSN can be used as a marker of neoplastic transformation of epithelial cells in pancreatic mucinous cysts. The findings can help identify neoplastic mucinous epithelium.
- Subjects
PANCREATIC cysts; MESOTHELIN; ANTIGENS; DUCTAL carcinoma; CANCER research
- Publication
American Journal of Clinical Pathology, 2014, Vol 142, Issue 3, p313
- ISSN
0002-9173
- Publication type
Article
- DOI
10.1309/AJCPDTTL2I5ECMFG