We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Anithiactin D, a Phenylthiazole Natural Product from Mudflat-Derived Streptomyces sp., Suppresses Motility of Cancer Cells.
- Authors
Pulat, Sultan; Yang, Inho; Lee, Jihye; Hwang, Sunghoon; Zhou, Rui; Gamage, Chathurika D. B.; Varlı, Mücahit; Taş, İsa; Yang, Yi; Park, So-Yeon; Hong, Ahreum; Kim, Jeong-Hyeon; Oh, Dong-Chan; Kim, Hangun; Nam, Sang-Jip; Kang, Heonjoong
- Abstract
Anithiactin D (1), a 2-phenylthiazole class of natural products, was isolated from marine mudflat-derived actinomycetes Streptomyces sp. 10A085. The chemical structure of 1 was elucidated based on the interpretation of NMR and MS data. The absolute configuration of 1 was determined by comparing the experimental and calculated electronic circular dichroism (ECD) spectral data. Anithiactin D (1) significantly decreased cancer cell migration and invasion activities at a concentration of 5 μM via downregulation of the epithelial-to-mesenchymal transition (EMT) markers in A549, AGS, and Caco-2 cell lines. Moreover, 1 inhibited the activity of Rho GTPases, including Rac1 and RhoA in the A549 cell line, suppressed RhoA in AGS and Caco-2 cell lines, and decreased the mRNA expression levels of some matrix metalloproteinases (MMPs) in AGS and Caco-2 cell lines. Thus 1, which is a new entity of the 2-phenylthiazole class of natural products with a unique aniline-indole fused moiety, is a potent inhibitor of the motility of cancer cells.
- Subjects
CANCER cell motility; NATURAL products; STREPTOMYCES; CANCER cell migration; RHO GTPases
- Publication
Marine Drugs, 2024, Vol 22, Issue 2, p88
- ISSN
1660-3397
- Publication type
Article
- DOI
10.3390/md22020088