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- Title
Role of ApoA1 on high-density lipoprotein: an intervention with plant sterols in patients with hypercholesterolemia.
- Authors
San Mauro Martín, Ismael; Collado Yurrita, Luis; Cuadrado Cenzual, María Ángeles; Ciudad Cabañas, María José; Mendive Dubourdieu, Paula
- Abstract
<bold>Background: </bold>Numerous studies have shown an inverse association between cholesterol´s concentration associated with High-Density Lipoprotein Cholesterol (HDL-C) and cardiovascular risk. The present study intends to investigate the possible relation between Apolipoprotein A (ApoA1) and HDL-C as a new strategy to reduce cardiovascular risk.<bold>Aim: </bold>was determine the effect of ApoA1 in cholesterol ´s metabolism through its influence on HDL-C in young adult population.<bold>Methods: </bold>One clinical trial, controlled, randomized, double-blind, providing a commercial milk, "Naturcol", with sterols for 3 weeks (n = 19) and placebo (n = 16). A questionnaire Ad Hoc was designed and a complete anthropometric study was made. SPSS 21.0 was used to analyse the data.<bold>Results: </bold>Significant differences were observed between sterol milk and placebo in a single marker, Low-Density Lipoprotein Cholesterol (LDL-C). A linear dispersion of data between HDL-C and ApoA1 was found, both at the beginning and end of the intervention (Person Correlation = 0.846 and 0.903, respectively). High dependency measures by linear regression (R2= 0.715 and 0.816, respectively) were observed.<bold>Conclusion: </bold>A significant relation between HDL-C and ApoA1 was proven. Taking into account the importance that HDL-C levels seem to have on cardiovascular health, ApoA1 is presented as an important clinical marker to improve heart function as well as to reduce cardiovascular risk.
- Subjects
APOLIPOPROTEIN A; HIGH density lipoproteins; STEROLS; HYPERCHOLESTEREMIA; CARDIOVASCULAR diseases; CHOLESTEROL; CARDIOVASCULAR disease prevention; PHYTOSTEROLS; ANTHROPOMETRY; APOLIPOPROTEINS; COMPARATIVE studies; LOW density lipoproteins; RESEARCH methodology; MEDICAL cooperation; RESEARCH; STATISTICAL sampling; EVALUATION research; RANDOMIZED controlled trials; BLIND experiment; THERAPEUTICS
- Publication
Nutrición Hospitalaria, 2015, Vol 31, Issue 1, p494
- ISSN
0212-1611
- Publication type
journal article
- DOI
10.3305/nh.2015.31.1.8147