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- Title
Synthesis of new pyrrolo[3,4-b]indol-3-ones as latent substrates for pyrrolo[3,4-b]indoles.
- Authors
Saulnier, Mark G.; Schreiber, Steven M.; Cavanaugh, Kerri L.; Perni, Robert B.; Joyner, H. Howard; Gribble, Gordon W.
- Abstract
We report the synthesis of new examples of the 1,4-dihydropyrrolo[3,4-b]indol-3(2H)-one ring system via Fischer indolization between the appropriate phenylhydrazines and pyrrolidine-2,3-diones. Lithiation at the C-1 position with lithium diisopropylamide following by quenching with iodomethane affords 1-methyl-1,4-dihydropyrrolo[3,4-b]indol-3(2H)-ones in excellent yield.
- Subjects
INDOLE compounds; METHYL iodide; PHENYLHYDRAZINE; LITHIATION; INDOLE
- Publication
ARKIVOC: Online Journal of Organic Chemistry, 2021, Vol 2021, p15
- ISSN
1551-7004
- Publication type
Article
- DOI
10.24820/ark.5550190.p011.365