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- Title
Blood transcript analysis and metastatic recurrent small bowel carcinoid management.
- Authors
Modlin, Irvin M; Drozdov, Ignat; Bodei, Lisa; Kidd, Mark
- Abstract
<bold>Background: </bold>Detection of neuroendocrine tumor (NET) disease progression is a key issue in determining management. Currently, assessment is by imaging (MRI/CT and Octreoscan®) and plasma Chromogranin A (CgA) measurement.<bold>Case Presentation: </bold>We report use of a NET-specific multigene PCR-derived blood transcript signature (NET Index) to assess disease and correlated CgA and gene transcripts with MRI, CT, Octreoscan®, 11C-5HTP-PET/CT and (68)Ga-DOTA-PET/CT in a patient with NET.<bold>Conclusions: </bold>Our results identify limitations in evaluating disease status by CgA and identify that a PCR-based test is more sensitive. Alteration in NET blood gene transcript levels prior to image-based tumor confirmation suggests this parameter may also have utility as an index of therapeutic efficacy.
- Publication
BMC Cancer, 2014, Vol 14, Issue 1, p564
- ISSN
1471-2407
- Publication type
journal article
- DOI
10.1186/1471-2407-14-564