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- Title
On-chip mass spectrometric analysis in non-polar solvents by liquid beam infrared matrix-assisted laser dispersion/ionization.
- Authors
Urban, Raphael D.; Fischer, Tillmann G.; Charvat, Ales; Wink, Konstantin; Krafft, Benjamin; Ohla, Stefan; Zeitler, Kirsten; Abel, Bernd; Belder, Detlev
- Abstract
By the on-chip integration of a droplet generator in front of an emitter tip, droplets of non-polar solvents are generated in a free jet of an aqueous matrix. When an IR laser irradiates this free liquid jet consisting of water as the continuous phase and the non-polar solvent as the dispersed droplet phase, the solutes in the droplets are ionized. This ionization at atmospheric pressure enables the mass spectrometric analysis of non-polar compounds with the aid of a surrounding aqueous matrix that absorbs IR light. This works both for non-polar solvents such as n-heptane and for water non-miscible solvents like chloroform. In a proof of concept study, this approach is applied to monitor a photooxidation of N-phenyl-1,2,3,4-tetrahydroisoquinoline.
- Subjects
SOLVENT analysis; INFRARED lasers; ATMOSPHERIC ionization; LIQUIDS; DISPERSION (Chemistry); ELECTROSPRAY ionization mass spectrometry
- Publication
Analytical & Bioanalytical Chemistry, 2021, Vol 413, Issue 6, p1561
- ISSN
1618-2642
- Publication type
Article
- DOI
10.1007/s00216-020-03115-4