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- Title
New insights in the clockwork mechanism regulating lineage specification: Lessons from the Drosophila nervous system.
- Authors
Cattenoz, Pierre B.; Giangrande, Angela
- Abstract
ABSTRACT Background: Powerful transcription factors called fate determinants induce robust differentiation programs in multipotent cells and trigger lineage specification. These factors guarantee the differentiation of specific tissues/organs/cells at the right place and the right moment to form a fully functional organism. Fate determinants are activated by temporal, positional, epigenetic, and post-transcriptional cues, hence integrating complex and dynamic developmental networks. In turn, they activate specific transcriptional/epigenetic programs that secure novel molecular landscapes. Results: In this review, we use the Drosophila Gcm glial determinant as a model to discuss the mechanisms that allow lineage specification in the nervous system. The dynamic regulation of Gcm via interlocked loops has recently emerged as a key event in the establishment of stable identity. Gcm induces gliogenesis while triggering its own extinction, thus preventing the appearance of metastable states and neoplastic processes. Conclusions: Using simple animal models that allow in vivo manipulations provides a key tool to disentangle the complex regulation of cell fate determinants. Developmental Dynamics 244:332-341, 2015. © 2014 Wiley Periodicals, Inc.
- Publication
Developmental Dynamics, 2015, Vol 244, Issue 3, p332
- ISSN
1058-8388
- Publication type
Article
- DOI
10.1002/dvdy.24228