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- Title
Serum profile of pro- and anti-inflammatory cytokines in rats following implantation of low-temperature plasma-modified titanium plates.
- Authors
Walschus, Uwe; Hoene, Andreas; Patrzyk, Maciej; Finke, Birgit; Polak, Martin; Lucke, Silke; Nebe, Barbara; Schroeder, Karsten; Podbielski, Andreas; Wilhelm, Lutz; Schlosser, Michael
- Abstract
Surface modification of Titanium (Ti) by low-temperature plasma influences cell-material interactions. Therefore, this study aimed at examining serum cytokine levels and associations after intramuscular implantation ( n = 8 rats/group) of Ti-plates with Plasma Polymerized Allyl Amine (Ti-PPAAm), Plasma Polymerized Acrylic Acid (Ti-PPAAc), and without such layers (Ti-Controls). Pro-inflammatory (IL-2, IFNγ, IL-6) and anti-inflammatory (IL-4, IL-10, IL-13) cytokines were measured weekly for 56 days. Ti-PPAAm caused increased IL-2 (d7-14, d35), increased IFNγ (d35) and decreased IL-10 (d35, d49-56). Ti-PPAAc induced divergent anti-inflammatory cytokine changes with increased IL-4 (d28-56) and decreased IL-10 (d42-56). Ti-Controls elicited increased IL-2 (d42) and IFNγ (d35-42, d56). IL-6 was not detected and IL-13 only in three samples, thus they do not influence the response against these Ti implants. Correlation analysis revealed surface-dependent associations between cytokines indicating the involvement of different inflammatory cell populations. Concluding, different plasma modifications induce specific serum cytokine profiles and associations indicating distinct inflammatory responses.
- Subjects
CYTOKINES; ANTI-inflammatory agents; TITANIUM; PLASMA polymerization; LABORATORY rats; AMINES
- Publication
Journal of Materials Science: Materials in Medicine, 2012, Vol 23, Issue 5, p1299
- ISSN
0957-4530
- Publication type
Article
- DOI
10.1007/s10856-012-4600-z