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- Title
Therapieempfehlungen beim Frühkarzinom des Ösophagus: Endoskopische und chirurgische Optionen.
- Authors
Schlosser, T.; Hoffmeister, A.; Feisthammel, J.; Niebisch, S.; Thieme, R.; Gockel, I.
- Abstract
Background: Esophageal cancer represents a complex tumor entity with an increasing proportion of adenocarcinomas. Early esophageal cancer is staged as m1–m3 depending on the depth of infiltration into the mucosa and as sm1–sm3 depending on invasion into the submucosa. The risk of lymph node metastasis is strongly correlated with the depth of invasion and increases by leaps and bounds with submucosal infiltration. Material and methods: This review is based on publications retrieved by a selective database search (MEDLINE, PubMed, Cochrane Library, International Standard Randomised Controlled Trial Number, ISRCTN, registry) on the current management of early esophageal cancer. Results: The endoscopic diagnostics and evaluation of the dignity of superficial esophageal cancer by traditional staining techniques have been expanded by virtual chromoendoscopy. Endoscopic resection is the diagnostic and therapeutic procedure of choice for mucosal low risk adenocarcinomas (grade 1 or 2, no blood or lymph vessel invasion). Under certain prerequisites adenocarcinomas of the upper submucosa (sm1) can also be endoscopically removed. All other stages necessitate surgical treatment. In squamous cell carcinoma without risk factors a surgical oncological esophageal resection is indicated after infiltration of the third mucosal layer (m3). Endoscopic submucosal dissection (ESD) shows high rates of en bloc and R0 (curative) resections even with large lesions. Conclusion: Borderline cases between endoscopic and surgical treatment of early esophageal cancer necessitate an interdisciplinary approach and individually adapted management, which in the locally advanced stage are always embedded in a multimodal concept.
- Subjects
ENDOSCOPIC surgery; ESOPHAGEAL tumors; ESOPHAGECTOMY; TREATMENT of esophageal cancer; THERAPEUTICS
- Publication
Der Chirurg, 2021, Vol 92, Issue 12, p1077
- ISSN
0009-4722
- Publication type
Article
- DOI
10.1007/s00104-021-01513-7