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- Title
New Opportunities for the Synthesis of Quinoxaline-Substituted Heterocyclic and Aryl Moieties.
- Authors
Azev, Yu.; Kodess, M.; Ezhikova, M.; Gibor, A.; Baranov, V.; Ermakova, O.; Bakulev, V.
- Abstract
6.7-Difluoroquinoxaline ( I) reacted with dimedone, indandione, and 3-methyl-1-phenylpyrazol-5-one in DMSO solution in the presence of acid to form mono-substituted products IIa - c. Heating I with resorcinol in EtOH in the presence of acid gave resorcinol derivative IId. 6.7-Difluoroquinoxaline in the presence of base reacted with 3-methyl-1-phenylmethylpyrazol-5-one to form dipyrazolylmethane III and tetrapyrazolylethane derivative IV. Heating products IIa - c with N-methylpiperazine produced 7-methylpiperazine derivatives Va - c of 2-substituted quinoxalines.
- Subjects
QUINOXALINES; SUBSTITUENTS (Chemistry); HETEROCYCLIC compounds; ARYL group; MOIETIES (Chemistry); RESORCINOL
- Publication
Pharmaceutical Chemistry Journal, 2013, Vol 47, Issue 9, p498
- ISSN
0091-150X
- Publication type
Article
- DOI
10.1007/s11094-013-0989-z