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- Title
ACUTE MUSCLE TOXICITY FOLLOWING AN OLANZAPINE OVERDOSE: A CASE REPORT.
- Authors
Mihăilă, Zenaida-Andreea; Branea, Oana-Elena; Branea, Ioan-Alexandru; Lazăr, Alexandra
- Abstract
Background: Olanzapine is a frequently prescribed atypical antipsychotic drug and a common cause of voluntary intoxications. Acute muscle toxicity, also known as rhabdomyolysis, is a severe muscle injury resulting in muscle pain and necrosis, myoglobinuria and elevated serum creatin kinase levels. Objective: The aim of this study is to raise awareness on rare medical findings, such as acute muscle toxicity associated with olanzapine overdose. Material and methods: We present the case of a 31 year old female with prior history of depression who was admitted to the Emergency Department after being found lethargic, on her knees by her family, allegedly after ingesting 30 Olanzapine pills. Upon arrival, she was evaluated to GCS 8, her labs showed: CK=16.905(U/L), GFR=82,42(ml/min), GOT=215U/L) and after being evaluated, she was transferred to the ICU, where additional pathological discoveries were found: she had hyperchrome, highly concentrated urine and pressure injuries on both her knees and calves. Her labs displayed: CK=79.115(U/L), GFR=103,72(ml/min), GOT=1.156(U/L), for which she was given fluid therapy and a loop diuretic. The next day her labs elevated even further: CK=85.340(U/L), GOT= 2.066(U/L), and her left leg was edematous, thus a compartment syndrome suspicion was raised. Results: Immediately, continuous renal replacement therapy was initiated and eventually fasciotomy was successfully avoided. The postprocedural evolution was favorable and 10 days later her labs were within normal limits. Conclusions: Olanzapine overdose is in itself a rather difficult to manage intoxication and if associated with acute muscle toxicity, the treatment becomes even more challenging. In our case, continuous renal replacement therapy, although invasive and complex, was required for a proper outcome.
- Subjects
ROMANIA; DRUG overdose; OLANZAPINE; RHABDOMYOLYSIS; CONFERENCES &; conventions; DISEASE complications
- Publication
Acta Marisiensis. Seria Medica, 2024, Vol 70, p42
- ISSN
2668-7755
- Publication type
Article