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- Title
Simultaneous Analysis of Amphetamine-type Stimulants in Plasma by Solid-phase Microextraction and Gas Chromatography–Mass Spectrometry.
- Authors
Mariotti, Kristiane de Cássia; Schuh, Roselena S.; Ferranti, Priscila; Ortiz, Rafael S.; Souza, Daniele Z.; Pechansky, Flavio; Froehlich, Pedro E.; Limberger, Renata P.
- Abstract
Brazil is considered one of the countries with the highest number of amphetamine-type stimulant (ATS) users worldwide, mainly diethylpropion (DIE) and fenproporex (FEN). The use of ATS is mostly linked to diverted prescription stimulants and this misuse is widely associated with (ab)use by drivers. A validated method was developed for the simultaneous analysis of amphetamine (AMP), DIE and FEN in plasma samples employing direct immersion-solid-phase microextraction, and gas chromatographic/mass spectrometric analysis. Trichloroacetic acid 10% was used for plasma deproteinization. In situ derivatization with propylchloroformate was employed. The linear range of the method covered from 5.0 to 100 ng/mL. The detection limits were 1.0 (AMP), 1.5 (DIE) and 2.0 ng/mL (FEN). The accuracy assessment of the control samples was within 85.58–108.33% of the target plasma concentrations. Recoveries ranged from 46.35 to 84.46% and precision was <15% of the value of relative standard deviation. This method is appropriate for screening and confirmation in plasma forensic toxicology analyses of these basic drugs.
- Subjects
BRAZIL; AMPHETAMINES; GAS chromatography/Mass spectrometry (GC-MS); BLOOD plasma; FORENSIC toxicology
- Publication
Journal of Analytical Toxicology, 2014, Vol 38, Issue 7, p432
- ISSN
0146-4760
- Publication type
Article
- DOI
10.1093/jat/bku063