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- Title
La diagnosi del tumore del polmone nell’era delle terapie target. Il ruolo dello pneumologo interventista.
- Authors
Failla, Giuseppe; Agrusa, Laura Serafino; La Sala, Alba; Martucci, Paola; Campione, Severo
- Abstract
Lung cancer is the most lethal of all forms of cancer. In this context, minimally invasive diagnostic approaches are replacing more aggressive surgical ones for the diagnosis and staging of lung cancer. Advances in bronchoscopic technology have allowed for safe and increasingly effective tissue diagnosis of lung nodules. On the other hand, most diagnoses are still made in an advanced stage and also in this scenario, bronchoscopic techniques play a central role in diagnosis and staging. In this review, we offer a concise overview of the significant advances in the field of bronchoscopy and to put them into clinical context. We also address current diagnostic challenges associated with sampling central and peripheral lung lesions and make a concise description of laboratory techniques for proper sample handling. In the era of personalized therapies, obtaining adequate specimens is key to provide a specific histologic and molecular diagnosis of lung cancer. The relationship of target therapies with specific histologies and predictive biomarkers has made the handling of biopsies the key factor for success.
- Publication
Rassegna di Patologia dell'Apparato Respiratorio, 2021, Vol 36, Issue 1, p38
- ISSN
0033-9563
- Publication type
Article
- DOI
10.36166/2531-4920-A058