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- Title
Risk factors and outcome analysis of gram-positive and gram-negative neonatal sepsis: A case-control study.
- Authors
Bhargava, Aradhana; Gur, Renu; Kaur, Harjyot; Agarwal, Paras; Maheshwari, Monika; Roy, Ruma Dev
- Abstract
Background: In developing countries, neonatal sepsis is responsible for 30-50% of the total neonatal deaths. The aim of this study was to investigate the host related, clinical practice related and environment related risk factors for neonatal gram-positive sepsis (GPS) and gram-negative sepsis (GNS) and their effect on outcome. Methods: We conducted a case-control study including 50 neonates with Blood Stream Infections (BSI) caused by both susceptible and resistant bacteria and 50 controls without BSI. Results: Applying Chi square test of significance and running Logistic regression analysis it was observed that neonates with low birth weight, premature rupture of membranes, congenital anomalies (host related factors) exposure to broad spectrum antibiotics and steroids, caesarean section (clinical practice related factors), expressed milk/formula feeding, mechanical ventilation, and delay in enteral feeding (environmental factors) were the independent risk factors for blood stream infections (BSI) (p value <0.05). BSI caused by both gram-positive and gram-negative organisms increase mortality compared to the controls. The mortality rate tabulated for neonates with GPS was observed to be 45.9% and 28.6% for neonates with GNS. The odds of neonates with GPS and GNS to die are 3.55 and 6.29 times more respectively, than neonates not having sepsis. Conclusion: Morbidity and mortality due to BSI can be prevented by controlling the risk factors at an early stage.
- Subjects
INDIA; NEONATAL sepsis; LOW birth weight; BREASTFEEDING; CHI-squared test; CONFIDENCE intervals; GRAM-negative bacteria; GRAM-positive bacteria; LENGTH of stay in hospitals; MORTALITY; T-test (Statistics); LOGISTIC regression analysis; CASE-control method; ODDS ratio; DISEASE risk factors
- Publication
Canadian Journal of Infection Control / Revue Canadienne de Prévention des Infections, 2017, Vol 32, Issue 2, p98
- ISSN
1183-5702
- Publication type
Article