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- Title
Comparison of efficacy and cost of three different antimicrobial prophylaxis drugs in microsurgical transsphenoidal surgery.
- Authors
Ulutabanca, Halil; Kilic, Aysegul Ulu; Alp, Emine; Orhan, Tülay; Selçuklu, Ahmet; Doganay, Mehmet
- Abstract
Background: While some elective neurosurgery operations, such as craniotomy, cerebrospinal fluid shunting procedures and intrathecal pumps, have clear recommendations for antimicrobial prophylaxis (AMP), no comprehensive recommendations exist for transsphenoidal surgery (TSS). The aim of this study was to compare the efficacy and cost of three different AMP drugs in TSS. Method: A retrospective analysis of the clinical records of patients who underwent pituitary surgery between January 2012 and February 2016 was performed. TSS was performed via endonasal microsurgical approach. Patients were classified into three groups according to AMP regimen received. The cost analysis per patient was calculated in United States dollars. Results: We identified a total of 126 patients who underwent TSS. Of these, 32 (25.3%) received chemoprophylaxis with cefazolin, 50 (39.6%) with ceftriaxone, and 44 (34.9%) with fucidic acid drops. There were no cases of peri- or post-operative meningitis or any other procedure-associated infections in these patients. Cost-comparison of the three AMP regimens showed that cefazolin was more expensive than ceftriaxone and fusidic acid regimens. Conclusion: Three compared AMP drugs for TSS were found similarly effective with no reported infectious complication. The requirement of AMP for TSS is still controversial at hospitals where the infection rate is very low and the majority of infections are treatable.
- Subjects
TURKEY; STEROID drugs; STEROIDS; SURGICAL site infection prevention; COMPARATIVE studies; MICROSURGERY; NEUROSURGERY; PITUITARY diseases; COST analysis; CEFAZOLIN; TREATMENT effectiveness; RETROSPECTIVE studies; ANTIBIOTIC prophylaxis; CEFTRIAXONE; ECONOMICS; THERAPEUTICS
- Publication
Canadian Journal of Infection Control / Revue Canadienne de Prévention des Infections, 2017, Vol 32, Issue 1, p48
- ISSN
1183-5702
- Publication type
Article