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- Title
Late sodium current: incomplete inactivation triggers seizures, myotonias, arrhythmias, and pain syndromes.
- Authors
Fouda, Mohamed A.; Ghovanloo, Mohammad‐Reza; Ruben, Peter C.
- Abstract
Acquired and inherited dysfunction in voltage‐gated sodium channels underlies a wide range of diseases. In addition to defects in trafficking and expression, sodium channelopathies are caused by dysfunction in one or several gating properties, for instance activation or inactivation. Disruption of channel inactivation leads to increased late sodium current, which is a common defect in seizure disorders, cardiac arrhythmias skeletal muscle myotonia and pain. An increase in late sodium current leads to repetitive action potentials in neurons and skeletal muscles, and prolonged action potential duration in the heart. In this Topical Review, we compare the effects of late sodium current in brain, heart, skeletal muscle and peripheral nerves.
- Subjects
ACTION potentials; SODIUM; SODIUM channels; SEIZURES (Medicine); SKELETAL muscle; ARRHYTHMIA; SKELETAL muscle injuries
- Publication
Journal of Physiology, 2022, Vol 600, Issue 12, p2835
- ISSN
0022-3751
- Publication type
Article
- DOI
10.1113/JP282768