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- Title
Prognostic role of microRNA-155 in various carcinomas: Results from a meta-analysis.
- Authors
He, Jing; Zhang, Fengmei; Wu, Ying; Zhang, Wei; Zhu, Xiaoli; He, Xuelian; Zhao, Yuhang; Zhao, Yulan
- Abstract
BACKGROUND: Recent studies have shown that microRNAs (miRNA) have prognostic values in cancers. This meta-analysis seeks to summarize the global predicting role of miR-155 for survival in patients with a variety of carcinomas. METHODS: Eligible studies were identified through multiple search strategies. Data were extracted from studies investigating the relationship between miR-155 expression and survival in cancer patients. Combined hazard ratios (HRs) of miR-155 for outcome were analyzed. RESULTS: A total of 16 studies dealing with various carcinomas were included for this meta-analysis. For overall survival, higher miR-155 expression could significantly predict worse outcome with the pooled HR of 2.057 (95% CI: 1.392-3.039). For relapse or progress-free survival, elevated miR-155 was also a significant predictor, with a combined HR of 1.918 (95% CI: 1.311-2.806,). In addition, subgroup analysis showed that higher expression of miR-155 had the trends to predict worse outcome in lung cancer. However, the HRs did not reach the statistical significance. CONCLUSION: Our findings suggest that miR-155 detection has a prognostic value in cancer patients. Regularly measuring miR-155 expression may be useful in clinical practice.
- Subjects
META-analysis; MICRORNA; CANCER; DATA extraction; GENE expression; HEALTH outcome assessment
- Publication
Disease Markers, 2013, Vol 34, Issue 6, p379
- ISSN
0278-0240
- Publication type
Article
- DOI
10.1155/2013/856750